PEG 20000 was selected as cross-linking agent to prepare cross-linked sodium hyaluronate gel (CHA).Granulated CHA was obtained after a series of technologies:ethanol precipitation,drying,intermittent and instantaneous granulation,screening,redissolving and high-pressure steam sterilization.With the enzyme-resistant degradation rate of gel as index,effects of ethanol amount,drying temperature and drying time on preparation technology were investigated by orthogonal test.The optimum conditions of preparation technology were that the amount of 95% ethanol was 6.5 times of gel,drying the precipitation for 5.0h at 50.0℃。The enzyme-resistant degradation ratio of the granulated CHA was 80.53%,and the sodium hyaluronate(HA)hydrogel was 38.54%.
Reference from Journal of Henan University(Natural Science)
Writer:JIA Ke,ZHAO Yongliang,WANG Weiguo
-
singclean | 2017-08-30
Singclean Medical Shines at Mevos 2026 with Two New Singfiller Products, Ushering in a New Decade of Precision Filling -
singclean | 2017-08-30
Singclean Medical to Showcase Integrated Innovation Across Three Major International Exhibitions in 2026Hangzhou, China — Singclean Medical, a global innovator in medical aesthetics and advanced medical devices, will participate in three major international exhibitions in 2026 — Canton Fair (China), Hospitalar (Brazil), and WHX Miami (USA) — reinforcing its commitment to global expansion and innovation across diversified healthcare markets. -
singclean | 2017-08-30
Singclean Global Aesthetic Master Symposium Makes Landmark Debut in MonacoFrom March 26 to 28, Singclean Medical successfully hosted the second stop of the 2026 Singclean Global Aesthetic Master Symposium at AMWC Monaco. With its flagship filler brand Singderm at the forefront, the symposium featured two high-impact masterclasses that bridged anatomical precision with the artistry of Singderm.
